Doctoral (PhD) student position in Uremia-induced cardiovascular complications and potential for novel therapeutics - Hiring in process/Finished, not possible to apply

Do you want to contribute to improving human health?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

We belong to the Division of Renal Medicine at the Department for Clinical Science, Intervention and Technology. Our research profile is translational where we are utilizing both preclinical and clinical investigations to increase our understanding of why and how chronic kidney disease develops and proceeds towards kidney failure, and how we can ameliorate cardiovascular and cerebral complications under the uremic environment and apply novel screening technologies and therapeutics. We include several experimental set-ups both related to in vivo and ex vivo investigations to assess “Early vascular ageing phenotype” under uremia and identity novel therapeutic targets. The ongoing research is in close collaborations with clinical researchers at hospital site. The laboratory facilities reside in Neo at Campus Flemingsberg, a biomedical research building, that provides a creative and open environment that enables meetings, synergies, and exploration of scientific areas of interest across disciplines for mutual collaborations.

The doctoral student project and the duties of the doctoral student

As a doctoral student you will be involved in a project investigating different aspects of how and why chronic disease develops and is associated with several cardiovascular complications. The project includes epidemiological and experimental studies using both in vivo and ex vivo techniques to assess cardiovascular malfunctions and pathogenetic mechanisms involved, which could later be potentially targeted by novel therapeutics. As a doctoral student, you will carry out several different types of studies that will be associated with novel biomarkers and mechanisms, as well as screening of novel therapeutical agents. The overall goal of the research project is to better characterize the disease process and identify effective screening and treatment methods.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents
Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

To be accepted as a doctoral student, you must have a masters's degree in biomedicine or in a related field, e.g. nursing, medical education or life sciences.

It is also meriting to have previous experience of:

• working and studying in the research area scope cardiovascular health in uremia.
• expertise in the field of cardiovascular research based on studies during initial education.
• working hands-on with experimental methods (ELISA, IHC, IF and EndoPat), and associated statistical analyzes related to cardiorenal research.
• using or developing digital tools for data collection and communication.
• participation in scientific publications (would be of value to understand the potential in scientific writing and critical assessment of scientific literature.)

We are looking for a highly motivated and organized future PhD student that is passioned about translational research in the field of cardiorenal health and with good collaboration skills and the ability to create contacts and networks. In addition, we are looking for you who are quality-conscious, good at solving and responding to problems and understand the importance of sex and gender perspectives in the research and educational content. 

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Welcome to apply at the latest 12th June 2023. 

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

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