Doctoral student in molecular biology and epigenetics in liver metabolic disorders - Hiring in process/Finished, not possible to apply

Do you want to contribute to improving human health?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Fan group is located at Biosciences and Nutrition Unit of Department of Medicine Huddinge in the south campus of Karolinska Institute. The lab is mainly interested in epigenetic mechanisms in liver and cardiometabolic disorders. We are using state-of-the-art molecular biological techniques to investigate how chromatin remodelling events in the cells contribute to the development of diseases using both animal models and patient-derived biopsies and primary cells. 

The doctoral student project and the duties of the doctoral student

The student will mainly work with animal models and human cohorts to understand how transcription coregulators control epigenomics in the hepatocytes and how such molecular events are connected to lipid and cholesterol metabolism in the liver and are linked with MASLD and atherosclerosis.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

In order to fit for this position, we will expect the candidate to:
1) Have a strong molecular biology background and be familiar with chromatin analytical techniques such as ChIPseq, ATACseq, etc.
2) Have documented experience of liver or cardiometabolic research and understand the 
transcriptional mechanisms during the disease progression.
3) Have worked with animal (mouse) models and know most commonly used models for liver and 
cardiometabolic disorders. Expertise of primary hepatocyte isolation and culture is a huge plus.
4) Have bioinformatics skills and know basics of LINUX and R programming. Documented 
experience of multi-OMICs analysis (RNAseq, ChIPseq and ATACseq) is also a huge plus.
5) Have excellent communicaiton skills and team spirit. Be willing to collaborate and share the 
knowledge among the group.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

https://ki.se/en/research/research-areas-centres-and-networks/research-groups/liver-and-monocyte-remodelling-in-non-alcoholic-fatty-liver-disease-and-cardiovascular-disease-rongrong-fans-research-group

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