Doctoral (PhD) student position in Bioinformatics study of human skin wound healing - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The successful candidate will work in the wound healing research group headed by Dr. Ning Xu Landén (www.xulandenlab.com). The group belongs to the Division of Dermatology and Venereology, Department of Medicine Solna, and is physically located at the Centre of Molecular Medicine (CMM; https://www.cmm.ki.se). The research is performed in an interdisciplinary setting with strong collaboration with clinical departments and other national and international research groups. The group has extensive experience in non-coding RNA research with well-established methodologies for studying the expression and function of non-coding RNAs in skin wound healing.

The doctoral student project and the duties of the doctoral student

The chronic non-healing wound is a common and severe medical problem with unclear pathogenesis. The discovery of non-coding RNAs (ncRNAs) as powerful gene regulators provides hope in the quest to develop novel RNA-based treatments for a wide variety of diseases; however, the role of ncRNAs in human skin wound healing remains largely unexplored. We aim to reveal the expression and functional signatures of ncRNAs (primarily focusing on microRNAs, circular RNAs, and long ncRNAs) in human skin wound healing, and to identify ncRNAs that may be targeted in wound therapy. The current method spectrum of the group is centered around molecular biology, cell biology and biochemistry with human cells and tissues as well as mouse models but will be expanded.

We are looking for a doctoral student who will implement bioinformatic approaches to analyze data generated with various high-throughput technologies to profile expression and modification of RNAs, RNA-protein-DNA interactome, chromatin accessibility and DNA methylation in human skin/wound tissues and cells. The work will include design of study, data processing, quality control, statistical analyses, data interpretation and presentation of findings in the form of scientific publications. We offer a very stimulating and welcoming working environment in a group of motivated co-workers with diverse competencies.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

Required skills of the successful candidate are:

• A master degree in Bioinformatics, Computational Biology, Biostatistics, or a related discipline including where sufficient bioinformatic expertise is demonstrated in life sciences.
• Firm knowledge in Unix/Linux, R or Python. Experience in the analysis of next-generation sequencing data.
• Experience in big data management. Knowledge of relevant biological areas (chromatin and gene expression, genetics and epigenetics).
• Excellent knowledge in biostatistics.
• Experience in genomics data mining and visualization.
• Ability to deliver high-quality scientific outputs with a strong publication record.
• Good interpersonal skills and the ability to work both independently but also as a part of a large team.
• Good knowledge of spoken and written English and good communication skills.

We will look favorably upon if the candidate has experiences in one or more of the following areas:

• High-throughput screen deconvolution (genome editing including CRISPR-based, etc)
• Single-cell transcriptomics
• Integration of multiple genomics, epigenomics or proteomics datasets

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

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Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Location

The position is located within the Department of Medicine, Solna. The department consists of eleven divisions and each division consists of several research groups. The position is located within the research group headed by Dr. Ning Xu Landén (www.xulandenlab.com) at the Division of Dermatology and Venereology.

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