Doctoral student position in single cell research - Hiring in process/Finished, not possible to apply

Do you want to contribute to better health for all?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Ziegenhain lab is working on shedding light on central molecular processes in human cells, in particular with regards to the control of alternative splicing of transcribed mRNAs.
For this, the lab develops and employs cutting edge single-cell sequencing and computational approaches. The research group is part of the Division of Medical systems bioengineering at the department of Medical Biochemistry and Biophysics (MBB).

The doctoral student project and the duties of the doctoral student

Alternative splicing is a core mechanism essential for specifying cellular identities and correct functions in all human tissue contexts. While this topic has been studied intensively, there remains a distinct lack of knowledge in the precise regulatory language of alternative splicing events. Within this PhD project, we aim to study more closely the involvement of epigenetic cues and co- transcriptional mechanisms to alternative splicing outcomes through the lens of cutting-edge single- cell genomics methods. The doctoral student will develop multi-modal single cell technologies and use them for experiments to resolve regulatory mechanisms of alternative splicing. The project will require capacity to work independently, but also in a collaborative manner. 

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

Apart from meeting the general and specific eligibility requirements for doctoral students, the successful candidate will also need the required skills and personal qualities described below.

Required

• Good experience in molecular biology techniques and previous experience in single cell sequencing.
• Good communication skills.
• Self-driven motivation to pursue research with the ability to be flexible and engaged yet organized and goal oriented.

Desirable

• Proficiency in NGS data analysis using Sell scripts, R or Python.
• Experience in developing new experimental methods
• Experience in culturing of cell lines or human induced pluripotent stem cell lines 

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Last application day 13th of November.

For more information about the Ziegenhain lab and Department of Medical Biochemistry and Biophysics (MBB), please visit:

• https://ki.se/en/mbb/ziegenhain-lab
• https://ki.se/en/mbb/department-of-medical-biochemistry-and-biophysics

Want to make a difference? Join us and contribute to better health for all