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To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.
The Division of Rheumatology at the Department of Medicine is home to several research groups studying autoimmune disease with the aim to understand the pathogenesis and develop better diagnostics and treatment, as well as preventive strategies. The successful candidate for the PhD student position will be part of Marie Wahren-Herlenius’ group at the Center for Molecular Medicine.
Sjögren’s syndrome is a systemic rheumatic autoimmune condition, characterized by autoantibodies to the Ro/SSA and La/SSB antigens. During pregnancy, the maternal autoantibodies are transported across the placenta and affect the developing child. This may lead to a neonatal lupus syndrome, including a congenital heart block with high lethality. Previous clinical studies show that treatment by fluorinated steroids during the acute phase can revert the block and leads to substantially decreased mortality. This however requires surveillance by Doppler/echocardiography by a highly trained specialist during the susceptibility weeks. Currently, no other biomarker than Ro/SSA autoantibodies are known or used, meaning that congenital heart block only develops in 2/100 surveilled pregnancies. Although fetal lives can thus be saved, this is both inefficient use of health care resources and unnecessary stress for Ro/SSA positive pregnant mothers who may not be at risk. Further, while high dose steroids can reverse a developing AV block, this treatment has adverse effects including fetal growth disturbances. The lack of treatment alternatives is due to our lack of understanding of the pathogenic process in congenital heart block. This PhD project therefore aims at identifying clinically useful biomarkers and dissecting the pathogenic mechanisms of congenital heart block using bio banked and newly collected biomaterials from patients together with in vitro cellularly and molecularly based methods.
The student will be expected, under supervision, to obtain broad knowledge and systematic understanding of the research field and specialized knowledge in the project area. Further, the student should become familiar with research methodology in general and the methods specific to the project, and aquire the capacity for scholarly analysis and synthesis. The student is also expected to review and assess new and complex phenomena autonomously and critically. The student should also make an important contribution to the writing of scientific articles based on the project, and write a literature review of the research field ahead of the half-time review and thesis ahead of its defence.
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.
A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:
Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.
*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.
B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:
- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.
Follow the instructions on the web page English language requirements for doctoral education.
Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.
(A) and (B) can only be certified by the documentation requirement for doctoral education.
We are looking for an enthusiastic student with a medical degree and experience from the field of pediatrics and of immunological methods. Knowledge on and experience of working with human biomaterials and the Ro/SSA and La/SSB autoantibodies is a strong merit. The candidate should have the ability to develop into an independent scientist, but also have good abilities for teamwork and scientific collaboration with other scientists, post docs and students in the laboratory. The applicant must be organized, thorough, proactive and a talented problem solver. He/she is expected to interact with pediatric patients, so fluency in Swedish is a requirement. Further, the successful candidate will participate in national and international networks, so English language skills at a high level are required.
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.
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Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.
Your application must contain the following documents:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.
Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.
All applicants will be informed when the recruitment is completed.
The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Marie Wahren-Herlenius. We are located at the Center of Molecular Medicine, and the project is performed in close collaboration with the Pediatric Cardiology Unit at Astrid Lindgren's Children's Hospital.
Type of employment | PhD placement |
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Contract type | Full time |
Number of positions | 1 |
Full-time equivalent | 100 |
City | Solna |
County | Stockholms län |
Country | Sweden |
Reference number | STÖD 2-2996/2021 |
Contact |
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Union representative |
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Published | 17.Jun.2021 |
Last application date | 26.Jun.2021 11:59 PM CEST |