Doctoral (PhD) student position in Biological phenotypes in HFpEF explored through the adipoinsular axis and tissue saturation and their association with outcome - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group
Professor Lars H Lund leads our group and the group consists of multiple PhD students, post-docs and fellows, statisticians and data mangers, and research nurses. We also collaborate with other groups at Karolinska, throughout Sweden, and globally. We are involved in epidemiological, clinical and molecular aspects of heart failure.

The doctoral student project and the duties of the doctoral student
Heart failure affects approximately 2-3% of the adult Western population. It is categorized according to left ventricular ejection fraction as being preserved (HFpEF), moderately reduced (HFmrEF) or reduced (HFrEF). In HFpEF there is no evidence-based treatment reducing morbidity and mortality. To provide novel treatment targets we need to understand underlying pathophysiological mechanisms.

The goal of the doctoral project is to characterize HFpEF phenotypes through the adipoinsular axis and tissue saturation and to explore prognostic and regional differences in HFpEF phenotypes. The project includes clinical as well as laboratory work and will generate complex experimental data sets. Analysis requires the student to apply statistical methods including descriptive statistics and regression models added by bioinformatics to explore the HFpEF phenotype. During the doctoral student period, the student may also be allowed to make analyzes in larger epidemiological data sets. The student will interpret and present results in writing in of scientific papers and oral presentations.

What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities
We are seeking a highly motivated and inventive person with good communication skills and the ability to interact and work in a team as well as being able to work independently. We require previous experience in clinical work within heart failure and clinical heart failure research. The applicant should have good analytical skills and previous experience in quantitative data analysis. The ability to express yourself in writing and speech in fluent English is a requirement.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

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Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application must contain the following documents. We prefer that your application is written in English, but you can also apply in Swedish:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research - Analytical skill - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Location
The position is located within the Department of Medicine, Solna, at the division of Cardiology. The HFpEF program, phase 2 trials, biomarker and imaging research is led by Camilla Hage, RN, PhD and the registry-based, big data and epidemiology research is led by Gianluigi Savarese, MD, PhD.

https://medarbetare.ki.se/orgid/520225

https://ki.se/en/meds/heart-failure-with-reduced-and-preserved-ejection-fraction-clinical-and-translational-aspects

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