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The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.
Do you want to contribute to top quality medical research?
To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.
The research group
The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof. Biomedicum houses approximately 1,200 researchers and other personnel and allow expensive equipment to be shared and utilised more effectively.
The main interest of the Simon research group is to understand molecular and cellular mechanisms underlying regeneration of tissues and body parts in salamanders. The group focuses mainly on neuronal regeneration in the central nervous system and on cell plasticity during limb regeneration. The Simon group has established strong scientific collaborations both in Sweden and abroad. All necessary technological platforms, such as animal facility, single cell sequencing, advanced microscopy are available.
The doctoral student project and the duties of the doctoral student
In contrast to mammals, salamanders have an exceptional ability to regenerate complex body parts, such as entire limbs, tails, jaws, lens and retina of the eye, cardiac muscle and substantial parts of their central nervous system. Regeneration in salamanders can occur after repeated injuries throughout the entire life span of the animal. These findings indicate, among other salamander-specific traits, that regenerative progenitor cells are not exhausted by age or the number of regeneration cycles. How such maintenance of cellular potential is achieved is particularly relevant in the context of this doctoral project. Previous studies identified the expansion of a several miRNA families in the genome of the salamander species the Simon group is studying. These miRNAs have been linked cellular reprogramming. The student will use a wide variety of methods, including in vivo cell tracking and CRISPR/Cas9 mediated genome editing, in order to investigate the role of these miRNAs during limb regeneration, with particular focus on cellular dedifferentiation.
What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.
Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.
A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:
Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.
*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.
B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:
- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.
Follow the instructions on the web page English language requirements for doctoral education.
Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.
(A) and (B) can only be certified by the documentation requirement for doctoral education.
Skills and personal qualities
We seek a student with a background in molecular biology, biomedicine or the equivalent. The candidate should have a good team spirit, be self-motivated and a keen interest in regeneration, reprogramming and stem cell biology. Experience in working with salamanders and/or stem cells is a plus. The student is required to have good communication skills in English (written and verbal).
Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.
Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.
Your application must contain the following documents. We prefer that your application is written in English, but you can also apply in Swedish:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.
Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research - Analytical skill - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.
All applicants will be informed when the recruitment is completed.
Want to make a difference? Join us and contribute to better health for all
Type of employment | PhD placement |
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Contract type | Full time |
First day of employment | According to agreement |
Number of positions | 1 |
Full-time equivalent | 100% |
City | Stockholm |
County | Stockholms län |
Country | Sweden |
Reference number | STÖD 2-5765/2020 |
Contact |
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Union representative |
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Published | 22.Dec.2020 |
Last application date | 10.Jan.2021 11:59 PM CET |