Doctoral(PhD) position in in Breast Cancer Characterization with Multimodal Data Integration of Spatial Genomics Data and Clinical Data.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Daublab is a pioneering research group at Karolinska Institutet, the department of Medicine, Huddinge and at the Science for Life Laboratory (SciLifeLab) in Stockholm. Our team leverages clinical samples, cutting-edge high-throughput sequencing data from the latest spatial genomics technologies, and advanced bioinformatics methods to unravel the gene regulatory mechanisms underlying fundamental biological processes. We aim to understand how these processes are disrupted in various diseases.

Our extensive collaborations with genome technology groups at SciLifeLab and across Sweden, as well as with clinical research teams at Karolinska Hospitals, enable us to focus our research on human health using human clinical samples.

The doctoral student project and the duties of the doctoral student

Multimodal data integration is crucial in enabling the comprehensive understanding of relationships within and between various layers of biological and clinical information. By integrating diverse data types, our team can better grasp the vast heterogeneity of diseases, leading to enhanced diagnostic accuracy and more effective screening techniques.

The doctoral student will integrate a diverse array of breast cancer genomics data, including spatial transcriptomics, spatial epigenomics, single-cell sequencing, extensive breast tissue section images, clinical data, and genome sequences. Some of these datasets were generated in our lab, while complementary data have been sourced from public repositories. The student will gain a deep understanding of the clinical aspects of breast cancer to assess the performance and relevance of the integrated data. Advanced computational methods, including Artificial Intelligence and machine learning, will be employed and, if necessary, specifically developed.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

You have a master's degree in bioinformatics, computer sciences, computational biology, or equivalent experience. You have good statistics knowledge and experience working with high-throughput sequencing data. You are proficient in data analysis using R and/ or Python in a Linux environment. You are highly self-motivated, productive, and like to work in an interdisciplinary research team.

We offer an international and outstandingly exciting work environment of the highest scientific quality in world-leading research groups in Sweden and collaboration with groups in Europe and Japan

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Links:

Carsten Daubs research group
Department of Medicine, Huddinge
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